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Automated inline self-calibration at Lonza

Full monitoring throughout bioprocess

For Lonza, process reliability and product quality are paramount. Fully automated and traceable calibration during the process can reduce the risk of undetected measurement errors to a minimum.

TrustSens, launch plant fermenter, self-calibration, temperature measurement


  • Early detection of temperature drifts

  • Short calibration intervals reduce the risk of incorrect temperature measurements

  • Maximum process safety and plant availability

  • Accuracy of 0.03°C is 10 times better compared to a standard Pt100 class AA sensor

  • Fully automated and traceable storage of last 350 calibrations

Christian Ebener, Automation Manager,
Bioproduction, Lonza, Visp

Our bioprocess plants require temperature sensors that are 100% reliable. With its automatic inline self-calibration function at 118°C, the TrustSens is a safe bet for us.

Christian Ebener, Automation Manager
Bioproduction, Lonza

Customer challenge

Plant downtime and calibration times should be reduced to a minimum. To keep the risks in bio production as low as possible, an increase in calibration
frequency is required. It should be possible to save time on installation, maintenance and monitoring and to perform these tasks safely and reliably. All specifications require a high level of product quality.

Our solution

The self-calibrating iTHERM TrustSens temperature sensor was used for test purposes over a period of four months in a buffer tank located in a pilot plant fermenter. This sensor is that it performs an automated inline self-calibration at 118°C during each SIP process (Steam in Place) and reports any deviations to the control system using the HART protocol. The average deviation of 0.03°C is also 10 times better than the maximum permitted error of a standard Pt100 class AA sensor.